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Azidothymidine potentiates the immunomodulatory function of interferon-α in adult T cell leukemia/lymphoma.

Xiaoyi Yuan, Dian Zhu, Yi Liang, Liang Chen, Weijia Huang, Benquan Liu, Chenxin Tan, Jiajing Lin, Xiaorui Zuo, Zi-Wei Ye, Masao Matsuoka, Guangyong Ma

Molecular therapy : the journal of the American Society of Gene TherapySep 2, 2026PMID 42281209doi:10.1016/j.ymthe.2026.06.016 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260914-000001
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Adult T cell leukemia/lymphoma (ATLL), caused by human T cell leukemia virus type 1, is an aggressive malignancy with limited treatment options. Although the combination therapy of azidothymidine (AZT) and interferon-α (IFN-α) has demonstrated clinical efficacy in ATLL, its underlying mechanism…

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