Publication
Lactate-Activated GPR132 Signaling Drives a Tumor Microenvironmental Autocrine Metabolic Loop in Kidney Cancer.
Dazhi Wang, Timothy M Horton, Kyutae David Lee, Ifeanyichukwu Chinedu Ogobuiro, Fatemeh Vatankhah, Isadora de Andrade, John C Pisano, Vijay S Thakur, Mia K Gurevich, Sam Taylor, Mohammad Alyamani, Durga Prasad Gannamedi, Daniel G Isom, David B Lombard, Anthony J Griswold, Nima Sharifi, Vanina T Tcheuyap, James Brugarolas, Mark L Gonzalgo, Oleksandr N Kryvenko, Scott M Welford
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- PubMed
- Retrieved
- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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UNLABELLED: Despite the presence of oxygen, tumors frequently preferentially perform fermentative glycolysis, producing lactate and acidifying the tumor microenvironment (TME). Although studies have observed that high concentrations of lactate in the TME help tumors gain a proliferative advantage,…
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Candidate 1
- cancerMalignant Kidney Neoplasmdictionary0.60
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