Publication
Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.
Yafang Zhou, Sha Cheng, Cheng Li, Xinyu Liu, Jia Yu, Gang Yu, Ping Yi, Xiaoping Zeng, Wei Tu, Xueling Meng, Kun Liu, Xiaolin Peng, Ningning Zan, Heng Luo, Bixue Xu, Guangcan Xu
- Source
- PubMed
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260915-000001
Abstract
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Based on the previously identified lead compound H1, a 4-trifluoromethyl-2-arylaminoquinoline derivative, this study designed and synthesized 13 novel derivatives to enrich structural diversity and optimize bioactivity, and further evaluated their SGK1 inhibitory activity and anti-prostate cancer…
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Candidate 1
- cancerMalignant Prostate Neoplasmdictionary0.60
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