Publication
Therapeutic targeting of IL-17A-driven PTGS2/NLRP3 inflammasome activation in juvenile myelomonocytic leukemia.
Santhosh Kumar Pasupuleti, Baskar Ramdas, Kanaka Sai Ram Padam, Rahul Kanumuri, Lakshmi Reddy Palam, Ramesh Kumar, Tzu-Chieh Ho, Alex G Lee, Wade D Clapp, Cheng-Kui Qu, Elliot Stieglitz, Kai Yang, Reuben Kapur
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- PubMed
- Retrieved
- Sep 30, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260930-000001
Abstract
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Juvenile myelomonocytic leukemia (JMML) is an aggressive pediatric myelodysplastic syndrome or myeloproliferative disorder for which hematopoietic stem cell transplantation remains the only curative option; however, outcomes are particularly poor in patients harboring PTPN11 (encodes SHP2…
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- cancerLeukemiadictionary0.60
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