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Intismeran Autogene Plus Pembrolizumab Versus Pembrolizumab Alone in High-Risk Resected Melanoma: 5-Year Update of the Randomized Phase IIb KEYNOTE-942 Study.

Adnan Khattak, Matteo S Carlino, Tarek Meniawy, George Ansstas, Matthew H Taylor, Kevin B Kim, Meredith McKean, Georgina V Long, Ryan J Sullivan, Mark Faries, Thuy T Tran, C Lance Cowey, Andrew Pecora, Theresa Medina, Victoria Atkinson, Clemens Krepler, Thomas Jemielita, Huzhang Mao, Jacky Chow, Laureen S Ojalvo, Janice M Mehnert, KEYNOTE-942 Investigators

Journal of clinical oncology : official journal of the American Society of Clinical OncologySep 10, 2026PMID 42223134doi:10.1200/JCO-26-00835 Journal ArticleClinical Trial, Phase IIRandomized Controlled TrialMulticenter StudypubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

Abstract

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Intismeran autogene (intismeran; formerly V940 or mRNA-4157) is an mRNA-based individualized neoantigen therapy. We report 5-year outcomes of intismeran plus pembrolizumab from the phase IIb KEYNOTE-942 study (ClinicalTrials.gov identifier: NCT03897881). Eligible patients with resected stage IIIB…

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Registered trialsNCT03897881

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