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Long-term outcomes of azacitidine, venetoclax, and gilteritinib in newly diagnosed FLT3-mutated AML.

Nicholas J Short, Hagop Kantarjian, Naval Daver, Roberta S Azevedo, Omer Karrar, Courtney D DiNardo, Tapan Kadia, Musa Yilmaz, Manuel Maroun, Maria Hachem, Gautam Borthakur, Ghayas C Issa, Elizabeth J Shpall, Uday Popat, Xuelin Huang, Wei Qiao, Lewis Nasr, Walid Macaron, Regina Abramova, Guillermo Garcia-Manero, Marina Konopleva, Farhad Ravandi

Blood advancesSep 8, 2026PMID 42200455doi:10.1182/bloodadvances.2026019841 PMC13528351Journal ArticleClinical Trial, Phase IIpubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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Among patients with FLT3-mutated acute myeloid leukemia (AML) who receive frontline azacitidine plus venetoclax, relapses are commonly driven by the expansion of the FLT3-mutated clone, supporting FLT3 inhibitor-based triplet lower-intensity regimens. We report long-term outcomes of a phase 2 study…

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Registered trialsNCT04140487

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