Publication
Trogocytosis-orchestrated CLDN18.2-"dressed" CD8+ T cells drive pancreatic cancer progression via glucose metabolic reprogramming-induced cytotoxicity debilitation and systematic immune senescence cascade.
Tianxing Zhou, Jingrui Yan, Yu Zhang, Guohua Mao, Tinghai Hu, Shangheng Shi, Fanyue Shao, Jingbo Xu, Yaqi Zhang, Yifei Wang, Zekun Li, Hongwei Wang, Song Gao, Tiansuo Zhao, Antao Chang, Chongbiao Huang, Jun Yu, Yukuan Feng, Xiuchao Wang, Yongjie Xie, Bin Wang, Chao Yang, Jihui Hao
- Source
- PubMed
- Retrieved
- Sep 11, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260911-000001
Abstract
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BACKGROUND: As it is a tumour-associated antigen in epithelial cells, research on claudin18.2 (CLDN18.2) has focused on its role as a therapeutic target in pancreatic cancers and its part in maintaining tight junctions. OBJECTIVE: We elucidate the role of trogocytosis-related CLDN18.2 in CD8+ T…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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