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MLN4924 promotes the transcriptional activation of BTG2 via the ROS/EGR1-mediated signaling axis to suppress acute myeloid leukemia progression.

Xiao Tang, Jinli Jian, Yuancheng Guo, Shujuan An, Long Zhao, Bei Liu

Acta biochimica et biophysica SinicaSep 25, 2026PMID 41496600doi:10.3724/abbs.2025194 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy characterized by a high relapse rate and a low survival rate. Although chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) have improved the prognosis for AML patients, the overall survival…

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