PIK3CA Q546E

SNV

Identifier: CI-VAR-00003545
Entity page: /variant/pik3ca-q546e ↗
Edges: 5

Neighbours: 1 cancers4 drugs
Drawn: 5 of 5 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PIK3CA Q546E predicts response to …PREDICTS_RESPONSE_TO4 of 4
→ predicts response to	Fulvestrantsmall_molecule 2 source records aggregated	sensitivity	A	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ predicts response to	Palbociclibsmall_molecule	sensitivity	A

PIK3CA Q546E has curated evidence in …HAS_EVIDENCE_INderived1 of 1
→ has curated evidence in	Malignant Breast Neoplasm 2 accepted items · levels A · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Malignant Breast Neoplasm	2	Curated	civic	graph →

PIK3CA Q546E has curated evidence in …HAS_EVIDENCE_INderived1 of 1

→ has curated evidence in

Malignant Breast Neoplasm

2 accepted items · levels A · 2 sensitivity / 0 resistance · 2 supports / 0 does not support

sensitivity

Malignant Breast Neoplasm

Curated

civic

graph →

Radial view

Every edge, grouped by relationship

Paths