Knowledge graph · Variant
PIK3CA E453K
SNV
- Identifier
- CI-VAR-00000747
- Entity page
- /variant/pik3ca-e453k ↗
- Edges
- 4
- Neighbours
- 1 cancers3 drugs
- Drawn
- 4 of 4 neighbours (cap 60); table lists every fetched edge
Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.
Most connectedLung Non-Small Cell Carcinoma 3,149Malignant Colorectal Neoplasm 1,866ABL1 298EGFR 276Imatinib 450Dasatinib 321
Neighbourhood
Radial view
Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.
Edges
Every edge, grouped by relationship
Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.
| Relationship | Neighbour | Direction | Evidence level | Cancer context | Support | Claim | Source | Expand |
|---|---|---|---|---|---|---|---|---|
| PIK3CA E453K predicts response to …PREDICTS_RESPONSE_TO3 of 3 | ||||||||
| → predicts response to | Fulvestrantsmall_molecule | sensitivity | A | Malignant Breast Neoplasm | 1 | Curated | civic | graph → |
| → predicts response to | Inavolisibsmall_molecule | sensitivity | A | |||||