NRAS Q61K

SNV

Identifier: CI-VAR-00003566
Entity page: /variant/nras-q61k ↗
Edges: 16

Neighbours: 6 cancers9 drugs
Drawn: 15 of 15 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
NRAS Q61K predicts response to …PREDICTS_RESPONSE_TO10 of 10
→ predicts response to	Belvarafenibsmall_molecule	sensitivity	C	Acral Lentiginous Melanoma	1	Curated	civic	graph →
→ predicts response to	Trametinibsmall_molecule	sensitivity	C

NRAS Q61K has curated evidence in …HAS_EVIDENCE_INderived6 of 6
→ has curated evidence in	Malignant Colorectal Neoplasm 2 accepted items · levels C, D · 1 sensitivity / 1 resistance · 2 supports / 0 does not support	mixed	C	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has curated evidence in	Acral Lentiginous Melanoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Acral Lentiginous Melanoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Serous Tumor 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Malignant Ovarian Serous Tumor	1	Curated	civic	graph →
→ has curated evidence in	Cutaneous Melanoma 2 accepted items · levels D · 1 sensitivity / 1 resistance · 2 supports / 0 does not support	mixed	D	Cutaneous Melanoma	2	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Neuroblastoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Neuroblastoma	1	Curated	civic	graph →

NRAS Q61K has curated evidence in …HAS_EVIDENCE_INderived6 of 6

→ has curated evidence in

Malignant Colorectal Neoplasm

2 accepted items · levels C, D · 1 sensitivity / 1 resistance · 2 supports / 0 does not support

mixed

Malignant Colorectal Neoplasm

Curated

civic

graph →

→ has curated evidence in

Acral Lentiginous Melanoma

1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support