ESR1 D538G

SNV

Identifier: CI-VAR-00000501
Entity page: /variant/esr1-d538g ↗
Edges: 4

Neighbours: 1 cancers5 drugs
Drawn: 6 of 6 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ESR1 D538G predicts response to …PREDICTS_RESPONSE_TO5 of 3
→ predicts response to	Hormone Therapy	resistance	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ predicts response to	Fulvestrantsmall_molecule	sensitivity	D

ESR1 D538G has curated evidence in …HAS_EVIDENCE_INderived1 of 1
→ has curated evidence in	Malignant Breast Neoplasm 3 accepted items · levels C, D · 2 sensitivity / 1 resistance · 2 supports / 1 does not support	mixed	C	Malignant Breast Neoplasm	3	Curated	civic	graph →

ESR1 D538G has curated evidence in …HAS_EVIDENCE_INderived1 of 1

→ has curated evidence in

Malignant Breast Neoplasm

3 accepted items · levels C, D · 2 sensitivity / 1 resistance · 2 supports / 1 does not support

mixed

Malignant Breast Neoplasm

Curated

civic

graph →

Radial view

Every edge, grouped by relationship

Paths