CDKN2A Loss

deletion cna

Identifier: CI-VAR-00002475
Entity page: /variant/cdkn2a-loss ↗
Edges: 18

Neighbours: 10 cancers5 drugs
Drawn: 15 of 15 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CDKN2A Loss predicts response to …PREDICTS_RESPONSE_TO7 of 7
→ predicts response to	Immune Checkpoint Inhibitor	resistance	B	Bladder Urothelial Carcinoma	1	Curated	civic	graph →
→ predicts response to	Palbociclibsmall_molecule	sensitivity	B

CDKN2A Loss prognostic in …PROGNOSTIC_IN1 of 1
→ prognostic in	Acute Lymphoblastic Leukemiahematologic_malignancy	supports	B	Acute Lymphoblastic Leukemia	1	Curated	civic	graph →

CDKN2A Loss prognostic in …PROGNOSTIC_IN1 of 1

→ prognostic in

Acute Lymphoblastic Leukemiahematologic_malignancy

supports

Acute Lymphoblastic Leukemia

Curated

civic

graph →

CDKN2A Loss has curated evidence in …HAS_EVIDENCE_INderived10 of 10
→ has curated evidence in	Lung Non-Small Cell Carcinoma 2 accepted items · levels B · 1 sensitivity / 1 resistance · 1 supports / 1 does not support	mixed	B	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has curated evidence in	Acute Lymphoblastic Leukemiahematologic_malignancy 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Acute Lymphoblastic Leukemia	1	Curated	civic	graph →
→ has curated evidence in	Bladder Urothelial Carcinoma 1 accepted items · levels B · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	B	Bladder Urothelial Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Biliary Tract Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Pancreatic Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Cutaneous Melanoma 2 accepted items · levels D · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	D	Cutaneous Melanoma	2	Curated	civic	graph →
→ has curated evidence in	Dermatofibrosarcoma Protuberans 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Dermatofibrosarcoma Protuberans	1	Curated	civic	graph →
→ has curated evidence in	Ewing Sarcoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Ewing Sarcoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Neoplasm 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Renal Cell Carcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Renal Cell Carcinoma	1	Curated	civic	graph →

CDKN2A Loss has curated evidence in …HAS_EVIDENCE_INderived10 of 10

→ has curated evidence in

Lung Non-Small Cell Carcinoma

2 accepted items · levels B · 1 sensitivity / 1 resistance · 1 supports / 1 does not support