ABL1 E255V

SNV

Identifier: CI-VAR-00000704
Entity page: /variant/abl1-e255v ↗
Edges: 8

Neighbours: 1 cancers6 drugs
Drawn: 7 of 7 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ABL1 E255V predicts response to …PREDICTS_RESPONSE_TO8 of 7
→ predicts response to	Imatinib Mesylatesmall_molecule 2 source records aggregated	resistance	C	Chronic Myeloid Leukemia, BCR-ABL1 Positive	2	Curated	civic	graph →
→ predicts response to	Bosutinibsmall_molecule	resistance

ABL1 E255V has curated evidence in …HAS_EVIDENCE_INderived1 of 1
→ has curated evidence in	Chronic Myeloid Leukemia, BCR-ABL1 Positive 11 accepted items · levels B, C, D · 1 sensitivity / 10 resistance · 8 supports / 3 does not support	mixed	B	Chronic Myeloid Leukemia, BCR-ABL1 Positive	11	Curated	civic	graph →

ABL1 E255V has curated evidence in …HAS_EVIDENCE_INderived1 of 1

→ has curated evidence in

Chronic Myeloid Leukemia, BCR-ABL1 Positive

11 accepted items · levels B, C, D · 1 sensitivity / 10 resistance · 8 supports / 3 does not support

mixed

Chronic Myeloid Leukemia, BCR-ABL1 Positive

Curated

civic

graph →

Radial view

Every edge, grouped by relationship

Paths