ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

NOT YET RECRUITING

Identifier: CI-TRIAL-00114376
Entity page: /trial/NCT07318389 ↗
Edges: 11

Neighbours: 2 cancers9 drugs
Drawn: 11 of 11 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer condition of …CONDITION_OFderived2 of 2
← condition of	Colorectal Neoplasm registry condition “Dynamic Tumor Resistance” mapped PROBABILISTIC	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
← condition of	Malignant Colorectal Neoplasm registry condition “Metastatic Colorectal Cancer” mapped CURATED_BROADER	—

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer intervention of …INTERVENTION_OFderived9 of 9
← intervention of	Adagrasibsmall molecule registry intervention “Adagrasib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Bevacizumabmonoclonal antibody registry intervention “Bevacizumab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Cetuximabmonoclonal antibody registry intervention “Cetuximab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Encorafenibsmall molecule registry intervention “Encorafenib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	FOLFIRI Regimen registry intervention “FOLFIRI” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	FOLFOX Regimen registry intervention “FOLFOX” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Panitumumabmonoclonal antibody registry intervention “Panitumumab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Sotorasibsmall molecule registry intervention “Sotorasib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Tucatinibsmall molecule registry intervention “Tucatinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer intervention of …INTERVENTION_OFderived9 of 9

← intervention of

Adagrasibsmall molecule

registry intervention “Adagrasib” (DRUG) mapped ALIAS

—

not mapped

Observed

clinicaltrials

graph →

← intervention of

Bevacizumabmonoclonal antibody

registry intervention “Bevacizumab” (DRUG) mapped ALIAS

—