Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RECRUITING

Identifier: CI-TRIAL-00115034
Entity page: /trial/NCT05786924 ↗
Edges: 20

Neighbours: 9 cancers5 drugs
Drawn: 14 of 14 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies condition of …CONDITION_OFderived15 of 15
← condition of	Colorectal Carcinoma registry condition “Colorectal Carcinoma” mapped ONTOLOGY_EXACT	—	—	Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
← condition of	Histiocytic and Dendritic Cell Neoplasm registry condition “Histiocytic Neoplasm” mapped ALIAS	—	—

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies intervention of …INTERVENTION_OFderived5 of 5
← intervention of	Cetuximabmonoclonal antibody registry intervention “Cetuximab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	FOLFIRI Regimen registry intervention “FOLFIRI” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Gemcitabinesmall molecule registry intervention “Gemcitabine” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Nab-paclitaxel registry intervention “Nab-paclitaxel” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Panitumumabmonoclonal antibody registry intervention “Panitumumab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies intervention of …INTERVENTION_OFderived5 of 5

← intervention of

Cetuximabmonoclonal antibody

registry intervention “Cetuximab” (DRUG) mapped ALIAS

—

not mapped

Observed

clinicaltrials

graph →

← intervention of

FOLFIRI Regimen

registry intervention “FOLFIRI” (DRUG) mapped ALIAS