First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RECRUITING

Identifier: CI-TRIAL-00117070
Entity page: /trial/NCT05768139 ↗
Edges: 12

Neighbours: 2 cancers10 drugs
Drawn: 12 of 12 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors condition of …CONDITION_OFderived2 of 2
← condition of	Adult Solid Neoplasm registry condition “Solid Tumors, Adult” mapped ALIAS	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
← condition of	Malignant Breast Neoplasm registry condition “Breast Cancer” mapped CURATED_EXACT	—

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors intervention of …INTERVENTION_OFderived10 of 10
← intervention of	Abemaciclibsmall molecule registry intervention “Abemaciclib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Anastrozolesmall molecule registry intervention “Anastrozole” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Exemestanesmall molecule registry intervention “Exemestane” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Fulvestrantsmall molecule registry intervention “Fulvestrant” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Imlunestrantsmall molecule registry intervention “Imlunestrant” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Letrozolesmall molecule registry intervention “Letrozole” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Metforminsmall molecule registry intervention “Metformin” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Palbociclibsmall molecule registry intervention “Palbociclib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Ribociclibsmall molecule registry intervention “Ribociclib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Tamoxifensmall molecule registry intervention “Tamoxifen” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors intervention of …INTERVENTION_OFderived10 of 10

← intervention of

Abemaciclibsmall molecule

registry intervention “Abemaciclib” (DRUG) mapped ALIAS

—

not mapped

Observed

clinicaltrials

graph →

← intervention of

Anastrozolesmall molecule

registry intervention “Anastrozole” (DRUG) mapped ALIAS

—