Knowledge graph · Trial
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
ACTIVE NOT RECRUITING
- Identifier
- CI-TRIAL-00109535
- Entity page
- /trial/NCT05753384 ↗
- Edges
- 1
- Neighbours
- 1 cancers
- Drawn
- 1 of 1 neighbours (cap 60); table lists every fetched edge
Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.
Most connectedLung Non-Small Cell Carcinoma 3,147Malignant Colorectal Neoplasm 1,866ABL1 298EGFR 276Imatinib 450Dasatinib 321
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Edges
Every edge, grouped by relationship
Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.
| Relationship | Neighbour | Direction | Evidence level | Cancer context | Support | Claim | Source | Expand |
|---|---|---|---|---|---|---|---|---|
| Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System condition of …CONDITION_OFderived1 of 1 | ||||||||
| ← condition of | Chronic Myeloid Leukemia, BCR-ABL1 Positive registry condition “Chronic Myeloid Leukemia” mapped ALIAS | — | — | Chronic Myeloid Leukemia, BCR-ABL1 Positive | 1 | Observed | clinicaltrials | graph → |
An edge is a relationship stated by a source (CIViC evidence item, ChEMBL indication or mechanism, openFDA approval) and kept with its native evidence level, direction and cancer context — CancerIndex never infers, merges or re-scales it. Rows marked are counts and measurements read from registries (ClinicalTrials.gov conditions and interventions, GDC/cBioPortal cohort frequencies ≥ 5 % with ≥ 20 cases affected, regulatory approval records): they say how often two entities co-occur in a registry, not that a source asserted a biological or clinical link. Trials are rolled up over the cancer and its descendants; approvals list authority, jurisdiction and date as published.