Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RECRUITING

Identifier: CI-TRIAL-00125600
Entity page: /trial/NCT05564377 ↗
Edges: 28

Neighbours: 7 cancers15 drugs
Drawn: 22 of 22 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial condition of …CONDITION_OFderived13 of 13
← condition of	Endometrial Carcinoma registry condition “Recurrent Endometrial Carcinoma” mapped CURATED_BROADER	—	—	Endometrial Carcinoma	1	Observed	clinicaltrials	graph →
← condition of	Fallopian Tube Carcinoma registry condition “Recurrent Fallopian Tube Carcinoma” mapped CURATED_BROADER

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial intervention of …INTERVENTION_OFderived15 of 15
← intervention of	Alpelisibsmall molecule registry intervention “Alpelisib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Binimetinibsmall molecule registry intervention “Binimetinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Fluorouracilsmall molecule registry intervention “Fluorouracil” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Fulvestrantsmall molecule registry intervention “Fulvestrant” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Ipatasertibsmall molecule registry intervention “Ipatasertib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Leucovorinsmall molecule registry intervention “Leucovorin” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Neratinibsmall molecule registry intervention “Neratinib Maleate” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Nilotinibsmall molecule registry intervention “Nilotinib Hydrochloride Monohydrate” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Olaparibsmall molecule registry intervention “Olaparib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Oxaliplatinsmall molecule registry intervention “Oxaliplatin” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Paclitaxelsmall molecule registry intervention “Paclitaxel” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Palbociclibsmall molecule registry intervention “Palbociclib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Panitumumabmonoclonal antibody registry intervention “Panitumumab” (BIOLOGICAL) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Selumetinibsmall molecule registry intervention “Selumetinib Sulfate” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Sotorasibsmall molecule registry intervention “Sotorasib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial intervention of …INTERVENTION_OFderived15 of 15

← intervention of

Alpelisibsmall molecule

registry intervention “Alpelisib” (DRUG) mapped ALIAS

—

not mapped

Observed

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