Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients

COMPLETED

Identifier: CI-TRIAL-00063155
Entity page: /trial/NCT03885830 ↗
Edges: 9

Neighbours: 3 cancers4 drugs
Drawn: 7 of 7 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients condition of …CONDITION_OFderived5 of 5
← condition of	Chronic Myeloid Leukemia, BCR-ABL1 Positive registry condition “Chronic Myeloid Leukemia” mapped ALIAS	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
← condition of	Chronic Myeloid Leukemia, BCR-ABL1 Positive registry condition “CML (Chronic Myelogenous Leukemia” mapped ALIAS

Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients intervention of …INTERVENTION_OFderived4 of 4
← intervention of	Bosutinibsmall molecule registry intervention “Bosutinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Dasatinibsmall molecule registry intervention “Dasatinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Imatinibsmall molecule registry intervention “Imatinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Nilotinibsmall molecule registry intervention “Nilotinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients intervention of …INTERVENTION_OFderived4 of 4

← intervention of

Bosutinibsmall molecule

registry intervention “Bosutinib” (DRUG) mapped ALIAS

—

not mapped

Observed

clinicaltrials

graph →

← intervention of

Dasatinibsmall molecule

registry intervention “Dasatinib” (DRUG) mapped ALIAS