XRCC1

X-ray repair cross complementing 1

Identifier: CI-GENE-00039004
Entity page: /gene/XRCC1 ↗
Edges: 12

Neighbours: 2 cancers10 variants
Drawn: 12 of 12 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
XRCC1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Lung Non-Small Cell Carcinomasubtype 2 source records aggregated	supports	B	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ associated with	Malignant Cervical Neoplasmcancer	supports

XRCC1 has variant …HAS_VARIANTderived10 of 10
→ has variant	Q399RSNV 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Cervical Neoplasm	2	Curated	civic	graph →
→ has variant	R194WSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.1015C>T (p.Arg339Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.*13AC[12]other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.*13AC[17]other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.1713G>A (p.Gly571=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.234C>T (p.Gly78=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.602-33C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.602-4A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006297.3(XRCC1):c.839G>A (p.Arg280His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

XRCC1 has variant …HAS_VARIANTderived10 of 10

→ has variant

Q399RSNV

2 accepted CIViC evidence items

—

Lung Non-Small Cell Carcinoma,Malignant Cervical Neoplasm

Curated

civic

graph →

→ has variant

R194WSNV

1 accepted CIViC evidence items