MRE11

MRE11 double strand break repair nuclease

Identifier: CI-GENE-00014869
Entity page: /gene/MRE11 ↗
Edges: 2,327

Neighbours: 2 cancers15 variants
Drawn: 17 of 17 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MRE11 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Malignant Prostate Neoplasmcancer	supports	B	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ associated with	Malignant Endometrial Neoplasmsubtype	supports	D

MRE11 has variant …HAS_VARIANTderived15 of 2,325show all (up to 200)
→ has variant	Frameshiftindel 1 accepted CIViC evidence items	—	—	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ has variant	Lossdeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has variant	NC_000011.10:g.(?_94420119)_(94437241_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.94456339dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.(?_94476279)_(94479771_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.94493863C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.9:g.(?_94194092)_(94212937_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.9:g.(?_94209449)_(94212048_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.3(MRE11):c.1226_1228delGAGdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.3(MRE11):c.-174T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.4(MRE11):c.1001G>A (p.Ser334Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.4(MRE11):c.1002C>G (p.Ser334Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.4(MRE11):c.1002C>T (p.Ser334=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.4(MRE11):c.1003T>C (p.Phe335Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005591.4(MRE11):c.1004T>C (p.Phe335Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MRE11 has variant …HAS_VARIANTderived15 of 2,325show all (up to 200)

→ has variant

Frameshiftindel

1 accepted CIViC evidence items

—

Malignant Prostate Neoplasm

Curated

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