Knowledge graph · Gene
APH1A
aph-1A gamma-secretase subunit
- Identifier
- CI-GENE-00011042
- Entity page
- /gene/APH1A ↗
- Edges
- 3
- Neighbours
- 2 cancers1 drugs
- Drawn
- 3 of 3 neighbours (cap 60); table lists every fetched edge
Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.
Most connectedLung Non-Small Cell Carcinoma 3,149Malignant Colorectal Neoplasm 1,866ABL1 298EGFR 276Imatinib 450Dasatinib 321
Neighbourhood
Radial view
Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.
Edges
Every edge, grouped by relationship
Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.
| Relationship | Neighbour | Direction | Evidence level | Cancer context | Support | Claim | Source | Expand |
|---|---|---|---|---|---|---|---|---|
| APH1A targets …TARGETS1 of 1 | ||||||||
| ← targets | Nirogacestatsmall_molecule | — | INHIBITOR | — | 1 | Curated | chembl | graph → |
| APH1A altered in cohorts of …ALTERED_INderived2 of 2 | ||||||||
| → altered in cohorts of | Lung Adenocarcinoma 34 / 50 cases (68 %) · ssm · CDDP_EAGLE-1 | |||||||