Hematologic Neoplasm with Germline Predisposition — knowledge graph · CancerIndex

Knowledge graph · Cancer

Hematologic Neoplasm with Germline Predisposition

hematologic malignancy

Identifier: CI-CAN-00000968
Entity page: /cancer/hematologic-neoplasm-with-germline-predisposition ↗
Edges: 16

Neighbours: 10 drugs6 trials
Drawn: 16 of 16 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Hematologic Neoplasm with Germline Predisposition investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10
→ investigated in trials for	Cytarabinesmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Hematologic Neoplasm with Germline Predisposition	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants

Hematologic Neoplasm with Germline Predisposition studied in …STUDIED_INderived6 of 6
→ studied in	NCT04726241Phase 1/Phase 2 · recruiting The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Myeloid Leukemia Associated with Down Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT05702645recruiting A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Myeloid Leukemia Associated with Down Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT02521493Phase 3 · active not recruiting Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Myeloid Leukemia Associated with Down Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT05146739Phase 1 · active not recruiting Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Myeloid Leukemia Associated with Down Syndrome	1	Observed	clinicaltrials	graph →
→ studied in	NCT04965597Phase 2 · completed Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Hematologic Neoplasm with Germline GATA2 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT05717634unknown Endometrial Changes in Breast Cancer Women. · condition mapped ALIAS · 6 trials mapped (4 active)	—	—	Transient Abnormal Myelopoiesis Associated with Down Syndrome	1	Observed	clinicaltrials	graph →