Castration-Sensitive Prostate Carcinoma

subtype

Identifier: CI-CAN-00007378
Entity page: /cancer/castration-sensitive-prostate-carcinoma ↗
Edges: 27

Neighbours: 15 drugs10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Castration-Sensitive Prostate Carcinoma approved for …APPROVED_FORderived2 of 2
← approved for	Enzalutamidesmall molecule FDA (US) · approved · 2020-08-04 · non‑metastatic castration‑sensitive prostate cancer (nmCSPC) with biochemical recurrence at high risk for metastasis (high-risk BCR) XTANDI…	—	approved	Nonmetastatic Castration-Sensitive Prostate Carcinoma	1	Regulatory	openfda	graph →
← approved for

Castration-Sensitive Prostate Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 15
→ investigated in trials for	Prednisonesmall molecule 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Abiraterone Acetatesmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Apalutamidesmall molecule 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Abirateronesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Degarelixother 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Enzalutamidesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Goserelinother 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Leuprolideother 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Bicalutamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Darolutamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Histrelinother 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Relugolixsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Talazoparibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Triptorelinother 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →

Castration-Sensitive Prostate Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 15

→ investigated in trials for

Prednisonesmall molecule

5 trials (3 active) · roll-up of the cancer and its descendants

—

Castration-Sensitive Prostate Carcinoma

Observed

Castration-Sensitive Prostate Carcinoma studied in …STUDIED_INderived10 of 10
→ studied in	NCT05241860Phase 2 · active not recruiting Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM) · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06931340Phase 3 · recruiting Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07466498Phase 2 · not yet recruiting Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06378866Phase 2 · recruiting Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial · condition mapped CURATED_BROADER · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04267887Phase 2 · active not recruiting Advanced ChemoHormonal Therapy for Treatment Naive Metastatic Prostate Cancer · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06244004Phase 2 · recruiting FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04734730Phase 2 · recruiting Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05733351Phase 1 · terminated Vudalimab (XmAb20717) in Combination With Standard of Care Treatment in Patients With Metastatic Castration Sensitive Prostate Cancer · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03649841Phase 2 · terminated Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Neutron Radiation Therapy in Treating Patients With Prostate Cancer · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03827473Phase 2 · terminated Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer · condition mapped ONTOLOGY_EXACT · 10 trials mapped (7 active)	—	—	Castration-Sensitive Prostate Carcinoma	1	Observed	clinicaltrials	graph →

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