Gene
SIM1
SIM bHLH transcription factor 1
Explore in graph →CI-GENE-00030669HGNC:10882 ENSG00000112246 NCBI 6492 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Acute Lymphoblastic Leukemia - Phase II TARGET-ALL-P2 | Acute Lymphoblastic Leukemia | Ssm | 52 | 768 | 6.8% | 89 | gdc |
| Count Me In (CMI): The Metastatic Prostate Cancer (MPC) Project |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.