Gene
SESN2
sestrin 2
Explore in graph →CI-GENE-00030387HGNC:20746 ENSG00000130766 NCBI 83667 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (8)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 27749842
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) blca_cornell_2016 | Bladder Urothelial Carcinoma | Ssm | 10 | 72 | 13.9% | 106 | cbioportal |
| Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022 | Endometrial Carcinoma | Ssm | 14 | 169 | 8.3% | 187 | cbioportal |
| Sarcoma (MSK, 2026) lms_msk_2026 | unmapped | Ssm | 3 | 38 | 7.9% | 138 | cbioportal |
| Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022 | Colorectal Adenocarcinoma | Ssm | 3 | 40 | 7.5% | 177 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.