Gene
PRKG1
protein kinase cGMP-dependent 1
Explore in graph →CI-GENE-00021017HGNC:9414 ENSG00000185532 NCBI 5592 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Count Me In (CMI): The Metastatic Breast Cancer (MBC) Project CMI-MBC | Malignant Breast NeoplasmCURATED_BROADER | Ssm | 6 | 174 | 3.4% | 70 | gdc |
| Breast Cancer (METABRIC, Nature 2012 & Nat Commun 2016) brca_metabric | Invasive Breast Carcinoma | Ssm | 13 | 2,433 | 0.5% | 150 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.