Gene
PLEKHG6
pleckstrin homology and RhoGEF domain containing G6
Explore in graph →CI-GENE-00020117HGNC:25562 ENSG00000008323 NCBI 55200 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Testicular Germ Cell Tumors TCGA-TGCT | Testicular Germ Cell Tumor | Ssm | 253 | 263 | 96.2% | 99 | gdc |
| Germ Cell Tumors and Shared Leukemias (MSK, J Clin Invest 2020) |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.