Gene
PLEKHG4B
pleckstrin homology and RhoGEF domain containing G4B
Explore in graph →CI-GENE-00020115HGNC:29399 ENSG00000153404 NCBI 153478 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (11)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial ALCHEMIST-ALCH | unmapped | Ssm | 500 | 1,170 | 42.7% | 6 | gdc |
| Rectal Adenocarcinoma (TCGA GDC, 2025) |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.