Gene
PKM
pyruvate kinase M1/2
Explore in graph →CI-GENE-00019970HGNC:9021 ENSG00000067225 NCBI 5315 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 32332851
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) utuc_msk_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 3 | 82 | 3.7% | 168 | cbioportal |
| Bladder Cancer (MSK, Eur Urol 2014) blca_mskcc_solit_2014 | Bladder Urothelial Carcinoma | Ssm | 3 | 109 | 2.8% | 121 | cbioportal |
| Metastatic Melanoma (MSK, JCO Precis Oncol 2017) skcm_vanderbilt_mskcc_2015 | Cutaneous Melanoma | Ssm | 1 | 66 | 1.5% | 191 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.