Gene
PAK4
p21 (RAC1) activated kinase 4
Explore in graph →CI-GENE-00018827HGNC:16059 ENSG00000130669 NCBI 10298 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 32220886
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Breast Cancer (MSK, Clinical Cancer Res 2020) brca_pareja_msk_2020 | Invasive Breast Carcinoma | Ssm | 4 | 60 | 6.7% | 79 | cbioportal |
| Meningioma (University of Toronto, Nature 2021) mng_utoronto_2021 | Meningioma | Ssm | 4 | 115 | 3.5% | 45 | cbioportal |
| Lung Adenocarcinoma (TSP, Nature 2008) luad_tsp | Lung Adenocarcinoma | Ssm | 3 | 163 | 1.8% | 83 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.