Gene
NTHL1
nth like DNA glycosylase 1
Explore in graph →CI-GENE-00017342HGNC:8028 ENSG00000065057 NCBI 4913 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (4)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 38653864
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024 | unmapped | Ssm | 3 | 31 | 9.7% | 160 | cbioportal |
| IDH-mutated Diffuse Glioma (MSK, Clin Cancer Res 2024) difg_msk_2023 | Diffuse Glioma | Ssm | 1 | 40 | 2.5% | 183 | cbioportal |
| Endometrial Carcinoma cfDNA (MSK, Clin Cancer Res 2022) ucec_ccr_cfdna_msk_2022 | Endometrial Carcinoma | Ssm | 1 | 44 | 2.3% | 184 | cbioportal |
| MAPK on resistance to anti-HER2 therapy for breast cancer (MSK, Nat Commun. 2022) brca_mapk_hp_msk_2021 | Invasive Breast Carcinoma | Ssm | 1 | 61 | 1.6% | 190 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.