Gene
NOS3
nitric oxide synthase 3
Explore in graph →CI-GENE-00017003HGNC:7876 ENSG00000164867 NCBI 4846 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (7)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Refractory Cancers (RC) - Peripheral T-Cell Lymphoma (PTCL) RC-PTCL | Peripheral T-Cell Lymphoma, Not Otherwise Specified | Ssm | 15 | 58 | 25.9% | 50 | gdc |
| Adrenocortical Carcinoma (TCGA GDC, 2025) acc_tcga_gdc | Adrenal Cortical Carcinoma | Ssm | 4 | 90 | 4.4% | 49 | cbioportal |
| Adrenocortical Carcinoma (TCGA, PanCancer Atlas) acc_tcga_pan_can_atlas_2018 | Adrenal Cortical Carcinoma | Ssm | 4 | 91 | 4.4% | 87 | cbioportal |
| Triple-Negative Breast Cancer (FUSCC, Cell Research 2020) brca_fuscc_2020 | Invasive Breast Carcinoma | Ssm | 2 | 69 | 2.9% | 113 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.