Gene
MSH4
mutS homolog 4
Explore in graph →CI-GENE-00015160HGNC:7327 ENSG00000057468 NCBI 4438 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (6)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 27634761
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Lung Cancer (SMC, Cancer Research 2016) lung_smc_2016 | unmapped | Ssm | 4 | 22 | 18.2% | 199 | cbioportal |
| Histiocytosis Cobimetinib (MSK, Nature 2019) histiocytosis_cobi_msk_2019 | Histiocytic and Dendritic Cell Neoplasm | Ssm | 1 | 15 | 6.7% | 188 | cbioportal |
| Glioblastoma (CPTAC, Cell 2021) gbm_cptac_2021 | Diffuse Glioma | Ssm | 5 | 99 | 5.1% | 37 | cbioportal |
| CNS/Brain Cancer (CPTAC GDC, 2025) brain_cptac_gdc | unmapped | Ssm | 9 | 264 | 3.4% | 113 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.