Gene
MEFV
MEFV innate immunity regulator, pyrin
Explore in graph →CI-GENE-00012353HGNC:6998 ENSG00000103313 NCBI 4210 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (7)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 22622578
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Melanoma (Broad/Dana Farber, Nature 2012) skcm_broad_dfarber | Cutaneous Melanoma | Ssm | 5 | 26 | 19.2% | 105 | cbioportal |
| Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012 | Cholangiocarcinoma | Ssm | 1 | 8 | 12.5% | 101 | cbioportal |
| Breast Invasive Carcinoma (British Columbia, Nature 2012) brca_bccrc | Invasive Breast Carcinoma | Ssm | 2 | 65 | 3.1% | 153 | cbioportal |
| Lung Cancer in Never Smokers (NCI, Nature Genetics 2021) lung_nci_2022 | Lung Adenocarcinoma | Ssm | 4 | 232 | 1.7% | 131 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.