Gene
MADD
MAP kinase activating death domain
Explore in graph →CI-GENE-00011806HGNC:6766 ENSG00000110514 NCBI 8567 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36585450
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metastatic Breast Cancer (AURORA US Network, Nat Cancer 2023) brca_aurora_2023 | Invasive Breast Carcinoma | Ssm | 15 | 134 | 11.2% | 112 | cbioportal |
| Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014 | Pancreatic Acinar Cell Carcinoma | Ssm | 2 | 23 | 8.7% | 151 | cbioportal |
| Ovarian Serous Cystadenocarcinoma (TCGA, Firehose Legacy) ov_tcga | High-Grade Serous Ovarian Cancer | Ssm | 6 | 316 | 1.9% | 144 | cbioportal |
| Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) ov_tcga_pub | High-Grade Serous Ovarian Cancer | Ssm | 6 | 316 | 1.9% | 137 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.