Gene
KLHL4
kelch like family member 4
Explore in graph →CI-GENE-00007037HGNC:6355 ENSG00000102271 NCBI 56062 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (4)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 22561520
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012 | Cholangiocarcinoma | Ssm | 1 | 8 | 12.5% | 89 | cbioportal |
| Colorectal Adenocarcinoma (TCGA, Firehose Legacy) coadread_tcga | Colorectal Adenocarcinoma | Ssm | 16 | 223 | 7.2% | 132 | cbioportal |
| Colorectal Adenocarcinoma (TCGA, Nature 2012) coadread_tcga_pub | Colorectal Adenocarcinoma | Ssm | 16 | 224 | 7.1% | 133 | cbioportal |
| Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018 | Uterine Malignant Mixed Mesodermal (Mullerian) Tumor | Ssm | 3 | 57 | 5.3% | 136 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.