Gene
IRF1
interferon regulatory factor 1
Explore in graph →CI-GENE-00006320HGNC:6116 ENSG00000125347 NCBI 3659 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Acute Myeloid Leukemia (TCGA GDC, 2025) aml_tcga_gdc | Acute Myeloid Leukemia | Ssm | 1 | 72 | 1.4% | 173 | cbioportal |
| Myelodysplastic Syndromes (MDS IWG, IPSSM, NEJM Evidence 2022) mds_iwg_2022 | Myelodysplastic Syndrome | Ssm | 35 | 3,323 | 1.1% | 92 | cbioportal |
| Histiocytic and Dendritic Cell Neoplasms (MSK, 2025) hdcn_msk_2025 | Histiocytic and Dendritic Cell Neoplasm | Ssm | 2 | 1,270 | 0.2% | 83 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.