Gene
H3C6
H3 clustered histone 6
Explore in graph →CI-GENE-00004012HGNC:4769 ENSG00000274750 NCBI 8353 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 35235413
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022 | Colorectal Adenocarcinoma | Ssm | 3 | 45 | 6.7% | 150 | cbioportal |
| Sarcoma (MSK, 2026) lms_msk_2026 | unmapped | Ssm | 2 | 40 | 5% | 185 | cbioportal |
| Pancreatic Neuroendocrine Tumors (MSK, 2023) panet_msk_erc_2023 | unmapped | Ssm | 1 | 62 | 1.6% | 167 | cbioportal |
| MAPK on resistance to anti-HER2 therapy for breast cancer (MSK, Nat Commun. 2022) brca_mapk_hp_msk_2021 | Invasive Breast Carcinoma | Ssm | 1 | 122 | 0.8% | 158 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.