Gene
GGH
gamma-glutamyl hydrolase
Explore in graph →CI-GENE-00002967HGNC:4248 ENSG00000137563 NCBI 8836 CIViC Approved
Curated evidence
Clinical evidence (1)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-26
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21449674
- Run
- ING-CIVIC-20260926-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GGH Decreased RNA expression1 | ||||||||
| Fluorouracil | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID13311Reduced GGH expression by shRNA significantly sensitized HCT-116, HT-29, and SW620 colorectal cancer cells to fluorouracil. Across the DHFR/GGH experiments (note that these are summarized together in-… (full text at CIViC) PMID 21449674 · Muhale et al., 2011 · Open in CIViC | civic |
Cohorts
Alteration frequency by cohort (0)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
Data not yet available
No cohort frequency recorded for this gene.
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.