Gene
GCLC
glutamate-cysteine ligase catalytic subunit
Explore in graph →CI-GENE-00002854HGNC:4311 ENSG00000001084 NCBI 2729 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 32897884
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Germ Cell Tumors and Shared Leukemias (MSK, J Clin Invest 2020) gct_msk_2020 | unmapped | Ssm | 1 | 13 | 7.7% | 101 | cbioportal |
| Pancreatic Ductal Adenocarcinoma (CPTAC, Cell 2021) paad_cptac_2021 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.