Gene
FHIT
fragile histidine triad diadenosine triphosphatase
Explore in graph →CI-GENE-00001952HGNC:3701 ENSG00000189283 NCBI 2272 CIViC Approved
Curated evidence
Clinical evidence (1)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17382535
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FHIT Loss of expression1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID12748In functional preclinical analyses of colorectal cancer, loss of FHIT expression resulted in impaired apoptotic signaling and increased tumour cell survival. FHIT-deficient tumour cells showed reduced… (full text at CIViC) PMID 17382535 · Cao et al., 2006 · Open in CIViC | civic |
Cohorts
Alteration frequency by cohort (0)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
Data not yet available
No cohort frequency recorded for this gene.
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.