Gene
EIF2AK1
eukaryotic translation initiation factor 2 alpha kinase 1
Explore in graph →CI-GENE-00044431HGNC:24921 ENSG00000086232 NCBI 27102 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 31852831
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Brain Tumor PDXs (Mayo Clinic, Clin Cancer Res 2020) gbm_mayo_pdx_sarkaria_2019 | Diffuse Glioma | Ssm | 16 | 105 | 15.2% | 135 | cbioportal |
| Acute Myeloid Leukemia (OHSU, Cancer Cell 2022) aml_ohsu_2022 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.