Gene
DNASE2
deoxyribonuclease 2, lysosomal
Explore in graph →CI-GENE-00043651HGNC:2960 ENSG00000105612 NCBI 1777 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 24974848
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Thymic Epithelial Tumors (NCI, Nat Genet 2014) tet_nci_2014 | Thymus Epithelial Neoplasm | Ssm | 1 | 32 | 3.1% | 142 | cbioportal |
| Neuroblastoma (Broad, Nature 2015) nbl_ucologne_2015 | Neuroblastoma | Ssm | 1 | 56 | 1.8% | 184 | cbioportal |
| Thyroid Carcinoma (TCGA, Firehose Legacy) thca_tcga | Thyroid Gland Papillary Carcinoma | Ssm | 3 | 405 | 0.7% | 104 | cbioportal |
| Papillary Thyroid Carcinoma (TCGA, Cell 2014) thca_tcga_pub | Thyroid Gland Papillary Carcinoma | Ssm | 3 | 496 | 0.6% | 102 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.