Gene
DENND5B
DENN domain containing 5B
Explore in graph →CI-GENE-00043247HGNC:28338 ENSG00000170456 NCBI 160518 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (6)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Bladder Urothelial Carcinoma (TCGA, Firehose Legacy) blca_tcga | Bladder Urothelial Carcinoma | Ssm | 10 | 130 | 7.7% | 119 | cbioportal |
| Bladder Urothelial Carcinoma (TCGA, Nature 2014) blca_tcga_pub | Bladder Urothelial Carcinoma | Ssm | 9 | 130 | 6.9% | 160 | cbioportal |
| Pediatric Low-Grade Glioma (CTF, Acta Neuropathol 2021) lgg_ctf_synodos_2025 | Diffuse Glioma | Ssm | 1 | 31 | 3.2% | 148 | cbioportal |
| Thyroid Carcinoma (TCGA, Firehose Legacy) thca_tcga | Thyroid Gland Papillary Carcinoma | Ssm | 3 | 405 | 0.7% | 100 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.