Gene
COX2
Explore in graph →CI-GENE-00045046NCBI 4513 CIViC Approved
Curated evidence
Clinical evidence (1)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29491076
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| COX2 Overexpression1 | ||||||||
| Celecoxib | HER2 Negative Breast CancerUNRESOLVED | Predictive | B | Supports Sensitivity Response | 1 | submitted | EID10155Analysis of 156 breast cancer samples from the REMAGUS-02 randomized phase II trial indicated potential clinical significance of COX2 expression with celecoxib treatment. Patient population characteri… (full text at CIViC) PMID 29491076 · DE Cremoux et al., 2018 · Open in CIViC | civic |
Cohorts
Alteration frequency by cohort (0)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
Data not yet available
No cohort frequency recorded for this gene.
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.