Gene
AFP
alpha fetoprotein
Explore in graph →CI-GENE-00000650HGNC:317 ENSG00000081051 NCBI 174 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 34635660
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| RAD51B Associated Mixed Cancers (MSK, NPJ Breast Cancer 2021) mixed_msk_tcga_2021 | unmapped | Ssm | 1 | 4 | 25% | 129 | cbioportal |
| Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017 | Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type | Ssm | 1 | 16 | 6.3% | 94 | cbioportal |
| Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) prad_fhcrc | Prostate Adenocarcinoma | Ssm | 8 | 141 | 5.7% | 129 | cbioportal |
| Meningioma (University of Toronto, Nature 2021) mng_utoronto_2021 | Meningioma | Ssm | 3 | 115 | 2.6% | 55 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.