Gene
AACS
acetoacetyl-CoA synthetase
Explore in graph →CI-GENE-00000013HGNC:21298 ENSG00000081760 NCBI 65985 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (6)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 34635660
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| RAD51B Associated Mixed Cancers (MSK, NPJ Breast Cancer 2021) mixed_msk_tcga_2021 | unmapped | Ssm | 1 | 4 | 25% | 89 | cbioportal |
| Colon Adenocarcinoma (CaseCCC, PNAS 2015) coad_caseccc_2015 | Colon Adenocarcinoma | Ssm | 2 | 29 | 6.9% | 69 | cbioportal |
| Metastatic Renal Clear Cell Carcinoma (Phase 1 Biomarker Trial, Clin Cancer Res. 2016) - iAtlas Harmonized ccrcc_iatlas_choueiri_2016 | Clear Cell Renal Cell Carcinoma | Ssm | 1 | 16 | 6.3% | 154 | cbioportal |
| Meningioma (University of Toronto, Nature 2021) mng_utoronto_2021 | Meningioma | Ssm | 1 | 115 | 0.9% | 131 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.