Subtype
Rectal Neoplasm
CI-CAN-00006564Explore in graph →
Non-malignant434 active trials1 approved drugs5 evidence items
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Subtype
CI-CAN-00006564Explore in graph →
Clinical trials
1,773 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT05241574 | Planned Non-operative Management for Rectal Cancer | unknown | Phase 2 | 23 | Maria Sklodowska-Curie National Research Institute of OncologyOTHER | 1 | Feb 15, 2022 | clinicaltrials |
| NCT02465593 | A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer | terminated | Phase 1 / Phase 2 | 32 | PharmaEngineINDUSTRY | 1 | Jan 11, 2022 | clinicaltrials |
| NCT00308516 | 5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer | completed | Phase 2 | 66 | SCRI Development Innovations, LLCOTHER | 1 | Dec 10, 2021 | clinicaltrials |
| NCT04418895 | Neoadjuvant Therapy for Localized Rectal Adenocarcinoma | withdrawn | Phase 2 | 0 | UNC Lineberger Comprehensive Cancer CenterOTHER | 1 | Nov 10, 2021 | clinicaltrials |
| NCT02319304 | Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma(GCC 1314) | terminated | Phase 2 | 3 | University of Maryland, BaltimoreOTHER | 1 | Nov 4, 2021 | clinicaltrials |
| NCT04109755 | Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer(PEMREC) | recruiting | Phase 2 | 25 | University Hospital, GenevaOTHER | 1 | Sep 30, 2021 | clinicaltrials |
| NCT04620473 | Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer | withdrawn | Phase 2 | 0 | Shanghai Minimally Invasive Surgery CenterOTHER | 0 | Sep 28, 2021 | clinicaltrials |
| NCT02948348 | Study to Nivolumab Following Preoperative Chemoradiotherapy | unknown | Phase 1 / Phase 2 | 90 | Takayuki YoshinoOTHER | 1 | Sep 16, 2021 | clinicaltrials |
| NCT02992886 | Preoperative Chemoradiotherapy With Raltitrexed for Intermediate or Locally Advanced Rectal Cancer in the Fit Elderly | completed | Phase 2 | 68 | Chinese Academy of Medical SciencesOTHER | 1 | Sep 9, 2021 | clinicaltrials |
| NCT00040599 | Safety Study of 90Y-hMN14 to Treat Colorectal Cancer | completed | Phase 1 / Phase 2 | 72 | Gilead SciencesINDUSTRY | 5 | Aug 19, 2021 | clinicaltrials |
| NCT00041652 | Safety Study of hMN14 to Treat Either Colorectal or Breast Cancer | completed | Phase 1 / Phase 2 | 30 | Gilead SciencesINDUSTRY | 1 | Aug 19, 2021 | clinicaltrials |
| NCT04989855 | Fruquintinib Plus PD-1 Antibody in pMMR / MSS Locally Advanced Rectal Cancer (LARC) With High Immune Score | unknown | Phase 2 | 48 | Sun Yat-sen UniversityOTHER | 1 | Aug 4, 2021 | clinicaltrials |
| NCT02864849 | Total Neoadjuvant Induction and Consolidation CapeOX Plus IMRT With Capecitabine for MRI Defined High-risk Rectal Cancer | completed | Phase 2 | 81 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jul 23, 2021 | clinicaltrials |
| NCT02393755 | Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer | completed | Phase 1 / Phase 2 | 42 | Roswell Park Cancer InstituteOTHER | 1 | Jul 8, 2021 | clinicaltrials |
| NCT01902953 | Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC) | completed | Phase 2 | 16 | Maimonides Medical CenterOTHER | 1 | Jun 23, 2021 | clinicaltrials |
| NCT04293419 | Durvalumab (MEDI4736) Plus Total Neoadjuvant Therapy (TNT) in Locally Advanced Rectal Cancer(DUREC) | unknown | Phase 2 | 58 | Grupo Espanol Multidisciplinario del Cancer DigestivoOTHER | 1 | Jun 21, 2021 | clinicaltrials |
| NCT04664504 | A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk | unknown | Phase 2 | 150 | Jing Jin, M.D.UNKNOWN | 1 | Jun 8, 2021 | clinicaltrials |
| NCT01437514 | Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer | terminated | Phase 2 / Phase 3 | 410 | West China HospitalOTHER | 1 | Jun 7, 2021 | clinicaltrials |
| NCT02340949 | Induction FOLFOX With or Without Aflibercept Followed by Chemoradiation in High Risk Locally Advanced Rectal Cancer(RIA) | completed | Phase 2 | 180 | Grupo Espanol Multidisciplinario del Cancer DigestivoOTHER | 0 | May 3, 2021 | clinicaltrials |
| NCT02167321 | Rectal Cancer, Adjuvant Chemotherapy, FOLFOX(5-fluorouracil/Leucovorin/Oxaliplatin), Total Mesorectal Excision | unknown | Phase 2 | 90 | Yonsei UniversityOTHER | 1 | Apr 22, 2021 | clinicaltrials |
| NCT02217020 | Neoadjuvant FOLFOXIRI Chemotherapy Alone for Locally Advanced Rectal Cancer(FORTUNE) | completed | Phase 2 | 100 | Sun Yat-sen UniversityOTHER | 1 | Apr 14, 2021 | clinicaltrials |
| NCT03484221 | Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer | unknown | Phase 2 | 30 | China Medical University, ChinaOTHER | 1 | Apr 14, 2021 | clinicaltrials |
| NCT04838496 | Induction Chemotherapy for Locally Advanced Rectal Cancer(MEND-IT) | unknown | Phase 2 | 128 | Catharina Ziekenhuis EindhovenOTHER | 1 | Apr 9, 2021 | clinicaltrials |
| NCT04423965 | A Trial of Neoadjuvant mFOLFOXIRI Versus CRT in the EMVI Positive LARC | unknown | Phase 2 | 220 | First Affiliated Hospital of Zhejiang UniversityOTHER | 1 | Mar 23, 2021 | clinicaltrials |
| NCT04801511 | Preoperative IMRT With Concurrent High-dose Vitamin C and mFOLFOX6 in Locally Advanced Rectal Cancer(CORT) | unknown | Phase 2 | 60 | Zhou FuxiangOTHER | 1 | Mar 17, 2021 | clinicaltrials |
| NCT04795180 | Pilot Randomized Evaluation of Butyrate Irrigation Before Ileostomy Closure on the Colonic Mucosa in Rectal Cancer Patients (BUTYCLO)(BUTYCLO) | completed | Phase 2 | 45 | Institut d'Investigació Biomèdica de Girona Dr. Josep TruetaOTHER | 1 | Mar 12, 2021 | clinicaltrials |
| NCT01037790 | Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer | completed | Phase 2 | 304 | Abramson Cancer Center at Penn MedicineOTHER | 1 | Mar 11, 2021 | clinicaltrials |
| NCT02641691 | Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum(NORMAL-R) | completed | Phase 2 | 20 | Washington University School of MedicineOTHER | 1 | Feb 18, 2021 | clinicaltrials |
| NCT04749381 | The Role of TCM on ERAS of Rectal Cancer Patients(RCT) | unknown | Phase 2 | 264 | Peking University Cancer Hospital & InstituteOTHER | 1 | Feb 11, 2021 | clinicaltrials |
| NCT01481545 | Bevacizumab With Pelvic Radiotherapy And Primary Chemotherapy in Patients With Poor-Risk Rectal Cancer(BRANCH) | completed | Phase 2 | 62 | National Cancer Institute, NaplesOTHER | 0 | Feb 3, 2021 | clinicaltrials |
| NCT03443661 | Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer | completed | Phase 2 | 50 | Aiping ZhouUNKNOWN | 1 | Feb 1, 2021 | clinicaltrials |
| NCT04674696 | Short-course Radiotherapy With Induction and Consolidation Chemotherapy in Patients With Locally Advanced Rectal Cancer(SHORT-ICAR) | unknown | Phase 2 | 54 | Instituto Nacional de Cancer, BrazilOTHER_GOV | 1 | Dec 19, 2020 | clinicaltrials |
| NCT03170115 | Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer(ICAR) | terminated | Phase 2 | 25 | Instituto Nacional de Cancer, BrazilOTHER_GOV | 1 | Dec 17, 2020 | clinicaltrials |
| NCT04663763 | Neoadjuvant Short-course Radiotherapy Followed by the Combination of Immunotherapy and Chemotherapy in Locally Advanced Rectal Cancer | unknown | Phase 2 | 40 | Zhejiang Cancer HospitalOTHER | 1 | Dec 11, 2020 | clinicaltrials |
| NCT04231552 | Preoperative Short Course Radiotherapy With Chemotherapy and Camerelizumab in Locally Advanced Rectal Cancer | unknown | Phase 1 / Phase 2 | 30 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER | 1 | Nov 30, 2020 | clinicaltrials |
| NCT04642924 | SGM-101 in Locally Advanced and Recurrent Rectal Cancer(SGM-LARRC) | unknown | Phase 2 / Phase 3 | 203 | Leiden University Medical CenterOTHER | 1 | Nov 24, 2020 | clinicaltrials |
| NCT01097239 | Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal Pelvic Cancer | withdrawn | Phase 1 / Phase 2 | 0 | Imperial College LondonOTHER | 1 | Nov 20, 2020 | clinicaltrials |
| NCT04621370 | A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer(PRIME-RT) | unknown | Phase 2 | 48 | Liz-Anne LewsleyOTHER | 0 | Nov 9, 2020 | clinicaltrials |
| NCT02010567 | Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer | terminated | Phase 1 / Phase 2 | 32 | UNC Lineberger Comprehensive Cancer CenterOTHER | 1 | Nov 3, 2020 | clinicaltrials |
| NCT00671645 | Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab, and Radiotherapy | terminated | Phase 2 | 8 | Austrian Breast & Colorectal Cancer Study GroupNETWORK | 1 | Oct 19, 2020 | clinicaltrials |
| NCT01397305 | An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer | completed | Phase 1 / Phase 2 | 24 | Isofol Medical ABINDUSTRY | 1 | Sep 9, 2020 | clinicaltrials |
| NCT01302613 | Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma | withdrawn | Phase 1 / Phase 2 | 0 | University of Texas Southwestern Medical CenterOTHER | 1 | Aug 20, 2020 | clinicaltrials |
| NCT04340401 | Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen | unknown | Phase 2 | 25 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jul 9, 2020 | clinicaltrials |
| NCT04443543 | An Adaptive-design Prospective Cohort Study of Watch and Wait Strategy in Patients With Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 222 | Fudan UniversityOTHER | 1 | Jun 30, 2020 | clinicaltrials |
| NCT01363843 | Complete Neoadjuvant Treatment for REctal Cancer (CONTRE) | completed | Phase 2 | 39 | William Sikov MDOTHER | 1 | Jun 11, 2020 | clinicaltrials |
| NCT04411524 | The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSI-H Locally Advanced Rectal Cancer | unknown | Phase 2 | 50 | Fudan UniversityOTHER | 1 | Jun 2, 2020 | clinicaltrials |
| NCT04411537 | The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSS Locally Advanced Rectal Cancer | unknown | Phase 2 | 50 | Fudan UniversityOTHER | 1 | Jun 2, 2020 | clinicaltrials |
| NCT04394598 | A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced Rectal Cancer | unknown | Phase 2 | 210 | Fudan UniversityOTHER | 1 | May 19, 2020 | clinicaltrials |
| NCT01609231 | A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025) | terminated | Phase 2 | 11 | Merck Sharp & Dohme LLCINDUSTRY | 0 | May 4, 2020 | clinicaltrials |
| NCT02887313 | FOLFOX6 Totally Neoadjuvant Chemoradiation Therapy in Locally Advanced Rectal Cancer: A Real World Study(FOTAC) | unknown | Phase 2 | 200 | Sun Yat-sen UniversityOTHER | 1 | May 4, 2020 | clinicaltrials |
Data updated 23 days agoSource updated Feb 15, 2022source: clinicaltrials